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. 2017 Feb 28;27(2):412-415.
doi: 10.4014/jmb.1611.11023.

Prebiotic Effects of Poly-Gamma-Glutamate on Bacterial Flora in Murine Gut

Hee-Eun Jin  1 , Jae-Chul Choi  1   2 , Yong Taik Lim  3 , Moon-Hee Sung  1   2
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Free article

Prebiotic Effects of Poly-Gamma-Glutamate on Bacterial Flora in Murine Gut

Hee-Eun Jin et al. J Microbiol Biotechnol. .
Free article

Abstract

Prebiotics improve the growth or activities of specific microbial genera and species in the gut microbiota in order to confer health benefits to the host. In this study, we investigated the effect of poly-gamma-glutamate (γ-PGA) as a prebiotic on the gut microbiota of mice and the organ distributions of γ-PGA in mice. Pyrosequencing analysis for 16S rRNA genes of bacteria indicated that oral administration of γ-PGA increased the abundance of Lactobacillales while reducing the abundance of Clostridiales in murine guts. It is suggested that oral administration of γ-PGA can be helpful for modulating the gut microbiota as a prebiotic.

Keywords: Poly-γ-glutamate; gut microbiota; organ distributions; prebiotics.

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