Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jan-Mar;9(1):12-18.

Cushing's disease: a multidisciplinary overview of the clinical features, diagnosis, and treatment

A Buliman  1 , L G Tataranu  2 , D L Paun  3 , A Mirica  3 , C Dumitrache  3
Affiliations
Review

Cushing's disease: a multidisciplinary overview of the clinical features, diagnosis, and treatment

A Buliman et al. J Med Life. 2016 Jan-Mar.

Abstract

Cushing's disease is considered a rare condition characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands. The clinical signs suggesting Cushing's disease, such as obesity, moon face, hirsutism, and facial plethora are already present on presentation. Endogenous hypercortisolism is associated with an increased risk of cardiovascular and metabolic manifestations, as well as respiratory disorders, psychiatric complications, osteoporosis and infections, leading to high rates of morbidity and mortality. It is vital to diagnose Cushing's disease as early as possible and to implement a treatment plan to lead to a successful prognosis and a low number of complications. The goal of this article was to review the clinical, diagnostic and treatment aspects of Cushing's disease using the most recent available guidelines.

Keywords: ACTH hypersecretion; Cushing’s disease; adrenocorticotropic hormone; corticotrophin-releasing hormone; pituitary adenoma.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Fig. 1The multimodal management of Cushing’s disease according to the new guidelines
See this image and copyright information in PMC

References

    1. Mark S. New York: Thieme Medical Publishers. 7 2010. Greenberg. Handbook of Neurosurgery.
    1. Newell-Price J, Bertagna X, Grossman AB, Nieman LK. Cushing’s syndrome. Lancet. Lancet. 2006;367:1605–1617. - PubMed
    1. Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM. The diagnosis of Cushing’s syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2008;93:1526–1540. - PMC - PubMed
    1. Ciubotaru V, Tataranu L, Paunescu D, Pruna V, Dricu A. Surgical management of non-functioning pituitary adenomas; The 7th Black Sea Neurosurgical Congress; 2011. Nov 17-19,
    1. Constantinovici A, Ciubotaru V, Ogrezeanu I. Principii de diagnostic si tratament in tumorile hipofizare. In: I Popescu I, Ciurea AV. Tratat de chirurgie Chirurgie, Ed. Academiei Romane, Bucuresti. 2007;2:256–266.

LinkOut - more resources