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Comment
. 2016 Dec 15;194(12):1441-1443.
doi: 10.1164/rccm.201607-1441ED.

Lost in Trans-IL-6 Signaling: Alveolar Type II Cell Death in Emphysema

Irina Petrache  1 , Karina Serban  1
Affiliations
Comment

Lost in Trans-IL-6 Signaling: Alveolar Type II Cell Death in Emphysema

Irina Petrache et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic of IL-6 trans-signaling pathway involvement in lung cell apoptosis and emphysema-like disease. Ruwanpura and colleagues (1) have demonstrated that inhibitors of IL-6 trans-signaling ameliorate apoptosis and emphysema-like phenotype induced by either cigarette smoke or by transgenic overexpression of gp130. These effects were associated with increased mechanistic target of rapamycin complex 1 (MTORC1) signaling and were inhibited by rapamycin. ATII = alveolar type II cells; MGK = megakaryocytes; sIL-6R = soluble IL-6 receptor; sgp130 = soluble gp130; TACE = ADAM 17.
See this image and copyright information in PMC

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References

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