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Comment
. 2016 Dec 15;194(12):1448-1451.
doi: 10.1164/rccm.201607-1431ED.

New Evidence for the Complexity of the Population Structure of Mycobacterium tuberculosis Increases the Diagnostic and Biologic Challenges

Véronique Dartois  1 , Kohta Saito  2 , Thulasi Warrier  2 , Carl Nathan  2
Affiliations
Comment

New Evidence for the Complexity of the Population Structure of Mycobacterium tuberculosis Increases the Diagnostic and Biologic Challenges

Véronique Dartois et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Intersubject variability in culture methods detecting Mycobacterium tuberculosis (Mtb) in sputum and implications for case detection. Each of the 110 subjects for whom results were analyzed is represented according to Mtb culture method positivity (9). Also represented are 22 subjects who were excluded from analysis but were described as having a positive mycobacterial growth indicator tube (MGIT), cfu, or GeneXpert test. The individual’s color classifies the predominant population identified, and they are grouped according to detection method positivity. Not all subjects’ sputum was tested by every method, and available information did not allow subgrouping by sputum smear positivity and GeneXpert positivity. In this patient population preselected by GeneXpert or smear positivity, no single culture method detected all cases. CF = culture filtrate; DCTB = differentially culturable tubercle bacilli; MPN = most probable number; Rpf = resuscitation-promoting factors.
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