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Meta-Analysis
. 2016 Dec;95(50):e5643.
doi: 10.1097/MD.0000000000005643.

A meta-analytic review of prevalence for Brugada ECG patterns and the risk for death

Xiao-Qing Quan  1 , Song Li, Rui Liu, Kai Zheng, Xiao-Fen Wu, Qiang Tang
Affiliations
Meta-Analysis

A meta-analytic review of prevalence for Brugada ECG patterns and the risk for death

Xiao-Qing Quan et al. Medicine (Baltimore). 2016 Dec.

Abstract

Background: The prevalence of Brugada ECG pattern (BrEP) is different in different regions, and its mean prevalence over the world is unknown. The risk of people with BrEP for death remains unknown. We performed a meta-analysis to determine the prevalence of BrEP and risk ratio (RR) for death.

Methods: Relevant studies published between July 1, 2000 and August 20, 2016, which contain prevalence and RR for all-cause death and cardiac death, were included. The prevalence and RR are analyzed using meta-analysis.

Results: We finally retrieved 24 studies of the prevalence for BrEP and 5 studies of the RR for all-cause death and cardiac death. The worldwide mean prevalence of BrEP is 0.4%, with highest in Asia (0.9%) and lowest in North America (0.2%). Additionally, the mean prevalence in male is 0.9%, whereas it is 0.1% in female. The RR of BrEP for all-cause death is 0.78 (95% confidence interval 0.45-1.37), and for cardiac death it is 0.92 (95% confidence interval 0.23-3.66).

Conclusion: The prevalence of BrEP is about 0.4% around the world with different prevalence in region and sex. Our study shows that BrEP may not be taken as a predictor of all-cause death and cardiac death.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow diagram of literature search and study selection.
Figure 2
Figure 2
Result of the mean global prevalence of Brugada ECG pattern (BrEP).
Figure 3
Figure 3
Result of the risk ratio (RR) of Brugada ECG pattern (BrEP) for all-cause death.
Figure 4
Figure 4
Result of the risk ratio (RR) of Brugada ECG pattern (BrEP) for cardiac death.
See this image and copyright information in PMC

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