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. 2016 Dec 16;18(24):6292-6295.
doi: 10.1021/acs.orglett.6b03156. Epub 2016 Dec 7.

Organocatalytic Enantioselective Continuous-Flow Cyclopropanation

Patricia Llanes  1 , Carles Rodríguez-Escrich  1 , Sonia Sayalero  1 , Miquel A Pericàs  1   2
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Organocatalytic Enantioselective Continuous-Flow Cyclopropanation

Patricia Llanes et al. Org Lett. .

Abstract

A set of six solid-supported diarylprolinol catalysts (varying on the anchoring strategy and the type of polymeric support) has been prepared and applied to the enantioselective cyclopropanation reaction. The selected candidate allows implementation of a long flow experiment (48 h) and generates a library of 12 cyclopropanes by sequential flow experiments. The mildness and utility of the method have enabled a telescoped process in which the outstream is directly used in a Wittig flow reaction.

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