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. 2016 Dec 16;18(24):6440-6443.
doi: 10.1021/acs.orglett.6b03339. Epub 2016 Dec 5.

Diastereospecific and Enantioselective Access to Dispirooxindoles from Furfurylcyclobutanols by Means of a Pd-Catalyzed Arylative Dearomatization/Ring Expansion Cascade

Jianchao Liu  1 , Hui Peng  1 , Lin Lu  1 , Xiaobing Xu  1 , Huanfeng Jiang  1 , Biaolin Yin  1
Affiliations

Diastereospecific and Enantioselective Access to Dispirooxindoles from Furfurylcyclobutanols by Means of a Pd-Catalyzed Arylative Dearomatization/Ring Expansion Cascade

Jianchao Liu et al. Org Lett. .

Abstract

We report a Pd-catalyzed arylative dearomatization/ring expansion cascade of furfurylcyclobutanols that involves a spiro π-allyl palladium intermediate and affords structurally novel dispirooxindoles containing two quaternary carbon centers in good yields with high step economy, diastereospecificity, and enantioselectivity.

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