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. 2016 Dec 16;81(24):12478-12481.
doi: 10.1021/acs.joc.6b02318. Epub 2016 Dec 1.

Synthesis of a Masked 2,3-Diaminoindole

Philip Z Mannes  1 , Evans O Onyango  1 , Gordon W Gribble  1
Affiliations

Synthesis of a Masked 2,3-Diaminoindole

Philip Z Mannes et al. J Org Chem. .

Abstract

A three-step synthesis of masked 2,3-diaminoindole 1 from 2-iodo-3-nitro-1-(phenylsulfonyl)indole (2) has been developed. Treatment of 1 with trifluoroacetic acid generates the unstable 2,3-diamino-1-(phenylsulfonyl)indole (3), which can be trapped with α-dicarbonyl compounds to afford 5H-pyrazino[2,3-b]indoles 7-10.

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