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. 2017 Jan 15;27(2):143-146.
doi: 10.1016/j.bmcl.2016.12.003. Epub 2016 Dec 2.

Imidazopyridyl compounds as aldosterone synthase inhibitors

Brent R Whitehead  1 , Michael M-C Lo  2 , Amjad Ali  2 , Min K Park  2 , Scott B Hoyt  2 , Yusheng Xiong  2 , Jiaqiang Cai  3 , Emma Carswell  3 , Andrew Cooke  3 , John MacLean  3 , Paul Ratcliffe  3 , John Robinson  3 , D Jonathan Bennett  3 , Joseph A Clemas  2 , Tom Wisniewski  2 , Mary Struthers  2 , Doris Cully  2 , Douglas J MacNeil  2
Affiliations

Imidazopyridyl compounds as aldosterone synthase inhibitors

Brent R Whitehead et al. Bioorg Med Chem Lett. .

Abstract

The inhibition of aldosterone synthase (CYP11B2) may be an effective treatment of hypertension and heart failure, among other ailments. Previously reported benzimidazole CYP11B2 inhibitors led the way for bioisosteric imidazopyridines that are both potent and selective over CYP11B1.

Keywords: Aldosterone; CYP11B2; Heart failure; Hypertension; Imidazopyridine.

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