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Review
. 2016 Nov 29;9(1):41.
doi: 10.1186/s40413-016-0131-2. eCollection 2016.

Asthma heterogeneity and severity

Tara F Carr  1 , Eugene Bleecker  2
Affiliations
Review

Asthma heterogeneity and severity

Tara F Carr et al. World Allergy Organ J. .

Abstract

Asthma is a common, chronic inflammatory airways disease characterized by a clinical syndrome of bronchial hyperresponsiveness, inflammation, and reversible airflow obstruction. Individuals with asthma can vary widely in clinical presentation, severity, and pathobiology. The incident factors, pathogenesis, prognosis, and treatment of asthma remain incompletely understood. Utilizing measurable characteristics of asthmatic patients, including demographic, physiologic, and biologic markers, can however identify meaningful phenotypic categories in asthma. Identification of these phenotypes may help improve precision therapeutics targeted toward an individual's' disease, and may identify strategies for preventing progression of disease severity.

Keywords: Heterogeneity; Phenotype; Severe asthma.

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Figures

Fig. 1
Fig. 1
Gene-environment interactions in susceptibility and severity of asthma
Fig. 2
Fig. 2
European respiratory society and American thoracic society task force; severe or therapy-resistant asthma: therapy
Fig. 3
Fig. 3
Severe asthma research program clinical clusters
See this image and copyright information in PMC

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