Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Sep 25;17(18):7325-31.
doi: 10.1093/nar/17.18.7325.

Rapid segregation of heteroplasmic bovine mitochondria

M V Ashley  1 , P J Laipis, W W Hauswirth
Affiliations
Free PMC article

Rapid segregation of heteroplasmic bovine mitochondria

M V Ashley et al. Nucleic Acids Res. .
Free PMC article

Abstract

By following the transmission of a heteroplasmic mitochondrial DNA mutation through four generations of Holstein cows, we have documented that substantial shifts in the levels of heteroplasmy can occur between single mammalian generations, that neutral mitochondrial genotypes can segregate in different directions in offspring of the same female, and that a return to homoplasmy may occur in only two or three generations. This apparently rapid rate of mitochondrial DNA segregation in mammals contrasts to the much slower rates observed previously in insects and suggest fundamental differences between taxa regarding the mechanisms of mitochondrial gene transmission.

PubMed Disclaimer

References

    1. Cell. 1977 Jul;11(3):571-83 - PubMed
    1. Mol Gen Genet. 1984;197(3):453-60 - PubMed
    1. Cell. 1988 Nov 18;55(4):601-10 - PubMed
    1. Genetics. 1983 Mar;103(3):513-27 - PubMed
    1. Genet Res. 1982 Aug;40(1):41-57 - PubMed

Publication types

Substances