Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy
- PMID: 27981569
- PMCID: PMC5359049
- DOI: 10.1002/cpt.590
Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity experienced in 30-40% of patients undergoing treatment with various chemotherapeutics, including taxanes, vinca alkaloids, epothilones, proteasome inhibitors, and thalidomide. Importantly, CIPN significantly affects a patient's quality of life. Recent genetic association studies are enhancing our understanding of CIPN pathophysiology and serve as a foundation for identification of genetic biomarkers to predict toxicity risk and for the development of novel strategies for prevention and treatment.
© 2016 American Society for Clinical Pharmacology and Therapeutics.
Conflict of interest statement
The authors declare no conflicts of interest.
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