Pharmacogenetic Implementation Lessons From the "Real World"
- PMID: 27981579
- PMCID: PMC5474210
- DOI: 10.1002/cpt.584
Pharmacogenetic Implementation Lessons From the "Real World"
Abstract
The manuscript "Anticoagulation Endpoints With Clinical Implementation of Warfarin Pharmacogenetic Dosing in a Real- World Setting: A Proposal for a New Pharmacogenetic Dosing Approach" describes process outcomes in an institutional program to use pharmacogenetic testing to optimize warfarin dose in a cohort of 257 patients of diverse ancestries. The strengths and weaknesses of the approach and program are discussed, along with the current and potential future status of warfarin as a model for pharmacogenetic testing.
© 2016 ASCPT.
Comment on
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Anticoagulation endpoints with clinical implementation of warfarin pharmacogenetic dosing in a real-world setting: A proposal for a new pharmacogenetic dosing approach.Clin Pharmacol Ther. 2017 May;101(5):675-683. doi: 10.1002/cpt.558. Epub 2016 Dec 29. Clin Pharmacol Ther. 2017. PMID: 28032893 Free PMC article.
References
-
- Furuya H, et al. Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy. Pharmacogenetics. 1995;5:389–392. - PubMed
-
- Rost S, et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature. 2004;427:537–541. - PubMed
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- Rieder MJ, et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. New England Journal of Medicine. 2005;352:2285–2293. - PubMed
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