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Comment
. 2017 Jul;102(1):25-27.
doi: 10.1002/cpt.584. Epub 2017 Mar 25.

Pharmacogenetic Implementation Lessons From the "Real World"

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Comment

Pharmacogenetic Implementation Lessons From the "Real World"

D M Roden. Clin Pharmacol Ther. 2017 Jul.

Abstract

The manuscript "Anticoagulation Endpoints With Clinical Implementation of Warfarin Pharmacogenetic Dosing in a Real- World Setting: A Proposal for a New Pharmacogenetic Dosing Approach" describes process outcomes in an institutional program to use pharmacogenetic testing to optimize warfarin dose in a cohort of 257 patients of diverse ancestries. The strengths and weaknesses of the approach and program are discussed, along with the current and potential future status of warfarin as a model for pharmacogenetic testing.

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References

    1. Furuya H, et al. Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy. Pharmacogenetics. 1995;5:389–392. - PubMed
    1. Rost S, et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature. 2004;427:537–541. - PubMed
    1. Rieder MJ, et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. New England Journal of Medicine. 2005;352:2285–2293. - PubMed
    1. Perera MA, et al. Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. The Lancet. 2013;382:790–796. - PMC - PubMed
    1. Arwood MJ, et al. Anticoagulation Endpoints with Clinical Implementation of Warfarin Pharmacogenetic Dosing in a Real-World Setting – A Proposal for a New Pharmacogenetic Dosing Approach. Clinical Pharmacology and Therapeutics. 2017 - PMC - PubMed

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