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. 2016 Dec 15;167(7):1669.
doi: 10.1016/j.cell.2016.11.044.

IL-17 Blockade in Psoriasis

Patrick R Burkett  1 , Vijay K Kuchroo  2
Affiliations
Free article

IL-17 Blockade in Psoriasis

Patrick R Burkett et al. Cell. .
Free article

Abstract

IL-17A both directly induces and synergizes with other cytokines to promote autoimmune tissue inflammation. Secukinumab and ixekizumab are monoclonal antibodies (mAb) that inhibit interleukin-17A. These two agents were recently approved for treatment of psoriasis, and secukinumab is also approved for treatment of two spondyloarthropathies, psoriatic arthritis and ankylosing spondylitis.

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