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Comment
. 2016 Dec 15;64(6):1015-1017.
doi: 10.1016/j.molcel.2016.11.035.

pRB Takes an EZ Path to a Repetitive Task

Ioannis Sanidas  1 , Nicholas J Dyson  2
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Comment

pRB Takes an EZ Path to a Repetitive Task

Ioannis Sanidas et al. Mol Cell. .
Free article

Abstract

Repetitive DNA elements are essential for genome function; in this issue of Molecular Cell, Ishak et al. (2016) describe a novel mechanism of epigenetic repression at these elements that requires pRB-dependent recruitment of EZH2.

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Comment on

  • An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences.
    Ishak CA, Marshall AE, Passos DT, White CR, Kim SJ, Cecchini MJ, Ferwati S, MacDonald WA, Howlett CJ, Welch ID, Rubin SM, Mann MRW, Dick FA. Ishak CA, et al. Mol Cell. 2016 Dec 15;64(6):1074-1087. doi: 10.1016/j.molcel.2016.10.021. Epub 2016 Nov 23. Mol Cell. 2016. PMID: 27889452 Free PMC article.

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