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Case Reports
. 2016 Nov 21;8(3):327-332.
doi: 10.1159/000452319. eCollection 2016 Sep-Dec.

Scleromyxedema without Paraproteinemia: Treatment with Thalidomide and Prednisolone

Sara Saniee  1 , Ghazaleh Davarnia  1
Affiliations
Case Reports

Scleromyxedema without Paraproteinemia: Treatment with Thalidomide and Prednisolone

Sara Saniee et al. Case Rep Dermatol. .

Abstract

Scleromyxedema is a rare and distinctive variant of cutaneous mucinoses of unknown etiology. It is presenting with generalized papular eruption and sclerodermoid induration. Numerous treatment modalities have been reported to produce partial or permanent responses. This study reports on a case of scleromyxedema without paraproteinemia in a subject who experienced a partial response to thalidomide and prednisolone.

Keywords: Mucinoses; Paraproteinemia; Scleromyxedema; Thalidomide.

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Figures

Fig. 1
Fig. 1
Scleromyxedema. Thickening of the skin of the forehead leading to furrows and folds.
Fig. 2
Fig. 2
Scleromyxedema. Numerous firm skin-colored papules on the chest.
Fig. 3
Fig. 3
Scleromyxedema. Thickening of the skin papules in a linear arrangement on the neck.
Fig. 4
Fig. 4
Scleromyxedema. Sclerodermoid papules are seen on the arm.
Fig. 5
Fig. 5
Pathology. Fibrosis, increased number of fibroblasts, deposits of mucin in the dermis.
See this image and copyright information in PMC

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References

    1. Rongioletti F, Rebora A. Updated classification of papular mucinosis, lichen myxedematosus, and scleromyxedema. J Am Acad Dermatol. 2001;44:273–281. - PubMed
    1. Breathnach SM. Mucinoses. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's Textbook of Dermatology. Vol. 3. Wiley Blackwell; 2010. p. 22.
    1. Dolenc-Voljc M, Jurcic V, Hocevar A, Tomsic M. Scleromyxedema with subcutaneous nodules: successful treatment with thalidomide and intravenous immunoglobulin. Case Rep Dermatol. 2013;5:309–315. - PMC - PubMed
    1. Rongioletti F, Rebora A. Mucinoses. In: Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. Vol. 1. Elsevier; 2012. p. 692.
    1. Caudill L, Howell E. Scleromyxedema: a case clinically and histologically responsive to intravenous immunoglobulin. J Clin Aesthet Dermatol. 2014;7:45–47. - PMC - PubMed

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