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. 2016;15(3):214-232.
doi: 10.1504/IJDMB.2016.077072.

The development of non-coding RNA ontology

Jingshan Huang  1 , Karen Eilbeck  2 , Barry Smith  3 , Judith A Blake  4 , Dejing Dou  5 , Weili Huang  6 , Darren A Natale  7 , Alan Ruttenberg  8 , Jun Huan  9 , Michael T Zimmermann  10 , Guoqian Jiang  11 , Yu Lin  12 , Bin Wu  13 , Harrison J Strachan  14 , Nisansa de Silva  15 , Mohan Vamsi Kasukurthi  16 , Vikash Kumar Jha  17 , Yongqun He  18 , Shaojie Zhang  19 , Xiaowei Wang  20 , Zixing Liu  21 , Glen M Borchert  22 , Ming Tan  23
Affiliations

The development of non-coding RNA ontology

Jingshan Huang et al. Int J Data Min Bioinform. 2016.

Abstract

Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of large amounts of ncRNA biological and clinical data.

Keywords: bio-ontologies; domain ontology; non-coding RNA; ontology development; reference ontology; semantic data annotation.

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Figures

Figure 1
Figure 1
The NCRO ontology construction procedure (see online version for colours)
Figure 2
Figure 2
Core terms and relations in the NCRO ontology (see online version for colours)
Figure 3
Figure 3
The NCRO ontology in the Protégé GUI (see online version for colours)
Figure 4
Figure 4
The NCRO ontology in the OBO-Edit GUI (1) (see online version for colours)
Figure 5
Figure 5
The NCRO ontology in the OBO-Edit GUI (2) (see online version for colours)
Figure 6
Figure 6
The NCRO ontology in the OBO-Edit GUI (3) (see online version for colours)
See this image and copyright information in PMC

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