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Review
. 2012:3:3.
Epub 2011 Mar 8.

The Phosphatidylinositol 3-kinase/Akt Signaling Pathway in Neuroendocrine Tumors

Yash R Somnay  1 , Muthusamy Kunnimalaiyaan  1
Affiliations
Review

The Phosphatidylinositol 3-kinase/Akt Signaling Pathway in Neuroendocrine Tumors

Yash R Somnay et al. Glob J Biochem. 2012.

Abstract

The phosphatidylinositol 3-kinase (PI3K)-Akt pathway is often aberrantly activated in neuroendocrine-derived cancers. Therefore, selectively targeting this pathway using small-molecule inhibitors may reduce neuroendocrine tumor burden, potentiate adjunct therapies, and achieve symptomatic control for patients with hormonally active and inoperable disease. Here, we discuss the role of the PI3K-Akt pathway in the malignant transformation of neuroendocrine tumors, specifically carcinoids and small cell lung cancers. The collective findings presented in this review propose that selective targeting of the PI3K-Akt pathway may mitigate neuroendocrine tumor progression, thus offering a viable therapeutic approach for managing systemic disease.

Keywords: ASCL1; Akt; Carcinoids; Chromogranin A; NE Tumors; Notch pathway; Raf-1 pathway; SCLC.

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