Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012:3:3.
Epub 2011 Mar 8.

The Phosphatidylinositol 3-kinase/Akt Signaling Pathway in Neuroendocrine Tumors

Yash R Somnay  1 , Muthusamy Kunnimalaiyaan  1
Affiliations
Review

The Phosphatidylinositol 3-kinase/Akt Signaling Pathway in Neuroendocrine Tumors

Yash R Somnay et al. Glob J Biochem. 2012.

Abstract

The phosphatidylinositol 3-kinase (PI3K)-Akt pathway is often aberrantly activated in neuroendocrine-derived cancers. Therefore, selectively targeting this pathway using small-molecule inhibitors may reduce neuroendocrine tumor burden, potentiate adjunct therapies, and achieve symptomatic control for patients with hormonally active and inoperable disease. Here, we discuss the role of the PI3K-Akt pathway in the malignant transformation of neuroendocrine tumors, specifically carcinoids and small cell lung cancers. The collective findings presented in this review propose that selective targeting of the PI3K-Akt pathway may mitigate neuroendocrine tumor progression, thus offering a viable therapeutic approach for managing systemic disease.

Keywords: ASCL1; Akt; Carcinoids; Chromogranin A; NE Tumors; Notch pathway; Raf-1 pathway; SCLC.

PubMed Disclaimer

References

    1. Sippel R, Carpenter J, Kunnimalaiyaan M, Chen H. The role of human achaete-scute homolog-1 in medullary thyroid cancer cells. Surgery. 2003;134:866–871. discussion 871-863. [PubMed: 14668716] - PubMed
    1. Van Gompel J, Sippel R, Warner T, Chen H. Gastrointestinal carcinoid tumors: factors that predict outcome. World J Surg. 2004;28:387–392. [PubMed: 14994141] - PubMed
    1. Sippel R, Carpenter J, Kunnimalaiyaan M, Lagerholm S, Chen H. Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol. 2003;285:G245–G254. [PubMed: 12851216] - PubMed
    1. Kunnimalaiyaan M, Ndiaye M, Chen H. Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery. 2006;140:1009–1014. discussion 1014-1005. [PubMed: 17188151] - PubMed
    1. Lal A, Chen H. Treatment of advanced carcinoid tumors. Curr Opin Oncol. 2006;18:9–15. [PubMed: 16357558] - PubMed

LinkOut - more resources