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Review
. 2016 Dec 1:6:255.
doi: 10.3389/fonc.2016.00255. eCollection 2016.

Potential Role of Circulating Tumor Cell Detection and Monitoring in Breast Cancer: A Review of Current Evidence

Malgorzata Banys-Paluchowski  1 , Natalia Krawczyk  2 , Tanja Fehm  2
Affiliations
Review

Potential Role of Circulating Tumor Cell Detection and Monitoring in Breast Cancer: A Review of Current Evidence

Malgorzata Banys-Paluchowski et al. Front Oncol. .

Abstract

The phenomenon of hematogenous tumor cell dissemination in patients with solid tumors has been extensively explored over the last decades. Breast cancer research investigated at first disseminated tumor cells in the bone marrow; however, the focus soon moved to circulating tumor cells (CTCs) in the peripheral blood as blood is easily accessible without an invasive procedure. The prognostic significance of CTC presence has been shown in large studies both in adjuvant and metastatic setting and commercially available detection assays have been evaluated for monitoring in clinical trials. Beyond detection and enumeration of CTCs, the characterization of single tumor cells may enhance our knowledge on disease progression and thus optimize treatment choices.

Keywords: biomarkers; breast cancer; circulating tumor cell; disseminated tumor cell; prognosis.

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References

    1. Ashworth TR. A case of cancer in which cells similar to those in tumors were seen in the blood after death. Aust Med J (1869) 14:146–9.
    1. Paget S. Distribution of secondary growths in cancer of the breast. Lancet (1889) 1:571.10.1016/S0140-6736(00)49915-0 - DOI - PubMed
    1. Braun S, Vogl FD, Naume B, Janni W, Osborne MP, Coombes RC, et al. A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med (2005) 353(8):793–802.10.1056/NEJMoa050434 - DOI - PubMed
    1. Banys M, Hartkopf AD, Krawczyk N, Kaiser T, Meier-Stiegen F, Fehm T, et al. Dormancy in breast cancer. Breast Cancer (Dove Med Press) (2012) 4:183–91.10.2147/BCTT.S26431 - DOI - PMC - PubMed
    1. Pantel K, Brakenhoff RH. Dissecting the metastatic cascade. Nat Rev Cancer (2004) 4(6):448–56.10.1038/nrc1370 - DOI - PubMed

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