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. 2016;1(7):1-5.
doi: 10.29245/2572.942x/2016/7.1064.

Obesity and Multiple Sclerosis Susceptibility: A Review

Milena A Gianfrancesco  1 , Lisa F Barcellos  1
Affiliations

Obesity and Multiple Sclerosis Susceptibility: A Review

Milena A Gianfrancesco et al. J Neurol Neuromedicine. 2016.

Abstract

Several studies conducted around the world over the last decade have demonstrated that early childhood and adolescent obesity are significant risk factors for MS susceptibility. This association has been largely confirmed in females, while evidence supporting a strong role for obesity and risk of MS in males has been mixed. Further, interaction between increased body mass index and genetic as well as environmental factors in MS susceptibility has been proposed, and evidence of a causal relationship has recently been established. In this review, we discuss findings supporting the significant association between obesity and MS, as well as identify areas for future investigation.

Keywords: Autoimmune disease; Body mass index; Epidemiology; Multiple sclerosis; Obesity; Susceptibility.

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Figures

Figure 1
Figure 1
Diagram demonstrating the association between increased body mass index (BMI) and multiple sclerosis (MS) onset, as well as potential confounding factors. Asterisk (*) indicates interaction between BMI and genetic or environmental risk factor.
See this image and copyright information in PMC

References

    1. Dilokthornsakul P, Valuck R, Nair K, et al. Multiple sclerosis prevalence in the United States commercially insured population. Neurology. 2016 Mar;6:1014–1021. - PMC - PubMed
    1. National Multiple Sclerosis Society. [Accessed September 20, 2016];Who gets MS? http://www.nationalmssociety.org/What-is-MS/Who-Gets-MS.
    1. Adelman G, Rane SG, Villa KF. The cost burden of multiple sclerosis in the United States: a systematic review of the literature. J Med Econ. 2013;16:639–647. - PubMed
    1. Barcellos LF, Sawcer S, Ramsay PP, et al. Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Human molecular genetics. 2006;15(18):2813–24. - PubMed
    1. Beecham AH, Patsopoulos NA, Xifara DK, et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013;45(11):1353–60. - PMC - PubMed

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