Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 May;21(5):1299-1308.
doi: 10.1007/s10461-016-1650-0.

Willingness to Use Pre-Exposure Prophylaxis (PrEP): An Empirical Test of the Information-Motivation-Behavioral Skills (IMB) Model among High-Risk Drug Users in Treatment

Roman Shrestha  1   2 , Frederick L Altice  3   4 , Tania B Huedo-Medina  3   5 , Pramila Karki  3   5 , Michael Copenhaver  3   5
Affiliations

Willingness to Use Pre-Exposure Prophylaxis (PrEP): An Empirical Test of the Information-Motivation-Behavioral Skills (IMB) Model among High-Risk Drug Users in Treatment

Roman Shrestha et al. AIDS Behav. 2017 May.

Abstract

Evidence from recent pre-exposure prophylaxis (PrEP) trials has demonstrated its safety and efficacy in significantly reducing the risk of HIV acquisition for those who are at considerable risk of acquiring HIV infection. With a rapid increase in the amount of research on the efficacy of PrEP for HIV prevention, complementary research on the willingness to use PrEP has grown, especially among MSM, but limited research has been focused among people who use drugs (PWUD). As part of the formative process, we utilized the information-motivation-behavioral skills (IMB) model of health behavior change to characterize and guide intervention development for promoting willingness to use PrEP among high-risk PWUD. The analysis included 400 HIV-negative high-risk PWUD enrolled in a community-based methadone maintenance treatment who reported drug- and/or sex-related HIV risk behaviors in the past 6-months. Analyses revealed support for the IMB model as PrEP-related behavioral skills were found to mediate the influence of PrEP-related information and motivation on willingness to use PrEP. The results provide evidence as to the utility of the IMB model to increase willingness to use PrEP among high-risk PWUD. It therefore makes an important contribution to our understanding of the applicability of theoretically-grounded models of willingness to use PrEP among high-risk PWUD, who are one of the key risk populations who could benefit from the use of PrEP.

Keywords: HIV; IMB model; People who use drugs; Pre-exposure prophylaxis; Structural equation modeling; Substance use.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
IMB model of health behavior change [28]
Figure 2
Figure 2
An empirical test of the IMB model of willingness to use PrEP using SEM with standardized path coefficients Note: Coefficients are standardized path coefficients. Overall model fit, χ2 (72, N = 400) = 113.08, p = 0.024, CFI = 0.95, TLI = 0.93 RMSEA = 0.09 (90% CI: 0.05 – 0.14) SRMR = 0.045. For tests of significance of individual paths, *p < 0.05, **p < 0.01 and ***p < 0.001. Legend: PrEP: pre-exposure prophylaxis
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. CDC. HIV surveillance report: Diagnoses of HIV infection in the United States and dependent areas, 2015. Vol. 27. Atlanta, GA: 2016.
    1. Arasteh K, Jarlais DCD, Perlis TE. Alcohol and HIV sexual risk behaviors among injection drug users. Drug & Alcohol Dependence. 2008;95(1):54–61. - PMC - PubMed
    1. Marshall BDL, Friedman SR, Monteiro JFG, Paczkowski M, Tempalski B, Pouget ER, Lurie MN, Galea S. Prevention And Treatment Produced Large Decreases In HIV Incidence In A Model Of People Who Inject Drugs. Health Affairs. 2014;33(3):401–409. - PMC - PubMed
    1. Strathdee SA, Hallett TB, Bobrova N, Rhodes T, Booth R, Abdool R, Hankins CA. HIV and risk environment for injecting drug users: the past, present, and future. The Lancet. 2010;376(9737):268–284. - PMC - PubMed
    1. Volkow ND, Montaner J. The urgency of providing comprehensive and integrated treatment for substance abusers with HIV. Health affairs (Project Hope) 2011;30(8):1411–1419. - PMC - PubMed

MeSH terms