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. 2017 Jan 19;56(4):1073-1076.
doi: 10.1002/anie.201610666. Epub 2016 Dec 19.

Buttressing Salicylaldehydes: A Multipurpose Directing Group for C(sp3 )-H Bond Activation

Akira Yada  1   2 , Wenqing Liao  1 , Yuta Sato  1 , Masahiro Murakami  1
Affiliations

Buttressing Salicylaldehydes: A Multipurpose Directing Group for C(sp3 )-H Bond Activation

Akira Yada et al. Angew Chem Int Ed Engl. .

Abstract

A palladium-catalyzed reaction of primary amines with iodoarenes produces γ-arylated primary amines. A bulky salicylaldehyde, which is marked as easily available, installable, removable, and recoverable, plays a key role in directing palladium to site-selectively activate the C-H bond located γ to the amino group.

Keywords: C−H activation; amines; arylation; palladium; reaction mechanisms.

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