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. 2017 Mar;7(3):261-267.
doi: 10.1002/alr.21885. Epub 2016 Dec 19.

The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

Giuseppe Brescia  1 , Umberto Barion  1 , Claudia Zanotti  1 , Luciano Giacomelli  2 , Alessandro Martini  1 , Gino Marioni  1
Affiliations

The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

Giuseppe Brescia et al. Int Forum Allergy Rhinol. 2017 Mar.

Abstract

Background: Predicting which patients are at a higher risk for recurrent chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most challenging problems in clinical rhinology. A direct association between CRSwNP recurrence rates and serum eosinophil and basophil counts was reported. This study aimed to identify best-fitting cutoffs for binarizing preoperative serum eosinophils and basophils (counts/percentages) for prognostic purposes in cases of CRSwNP recurrence after surgery. A secondary endpoint was to distinguish said cutoffs for prognosticating recurrence in subcohorts of patients with histologically diagnosed eosinophilic/non-eosinophilic CRSwNP.

Methods: A retrospective study was performed on 280 patients (127 eosinophilic and 153 non-eosinophilic CRSwNP) examining the prognostic role of serum eosinophil and basophil levels.

Results: For all patients examined, mean preoperative serum eosinophil and basophil levels were significantly higher in patients whose CRSwNP recurred. Patients with eosinophil counts ≥0.24 cells × 109 /L and percentages ≥3.7% had odds ratios (ORs) of 2.57 and 2.19 for recurrence; patients with basophil counts ≥0.03 cells × 109 /L and percentages ≥0.5% had ORs of 2.19 and 2.24, respectively. Among histologically eosinophilic CRSwNP patients, mean eosinophils and basophils (counts/percentages) were significantly higher in cases that recurred. Serum eosinophil and basophil values were directly correlated. The recurrence odds were OR 2.52 for high eosinophils (≥5.9%), and OR 2.52 and 2.69 for high basophils (≥0.04 cells × 109 /L and ≥0.5%, respectively).

Conclusion: High serum eosinophil and basophil values should be further investigated because they could pinpoint patients at higher risk of eosinophilic-type CRSwNP recurrence. These preliminary results support the increasing interest in the role of basophils in CRSwNP.

Keywords: ESS; eosinophils, basophils; recurrence; serum; sinonasal polyposis.

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