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Review
. 2017 Jan 17;8(3):3969-3979.
doi: 10.18632/oncotarget.13962.

Sex chromosome abnormalities and psychiatric diseases

Xinzhu Zhang  1 , Jian Yang  2 , Yuhong Li  1   2 , Xin Ma  1   2 , Rena Li  1   2   3
Affiliations
Review

Sex chromosome abnormalities and psychiatric diseases

Xinzhu Zhang et al. Oncotarget. .

Abstract

Excesses of sex chromosome abnormalities in patients with psychiatric diseases have recently been observed. It remains unclear whether sex chromosome abnormalities are related to sex differences in some psychiatric diseases. While studies showed evidence of susceptibility loci over many sex chromosomal regions related to various mental diseases, others demonstrated that the sex chromosome aneuploidies may be the key to exploring the pathogenesis of psychiatric disease. In this review, we will outline the current evidence on the interaction of sex chromosome abnormalities with schizophrenia, autism, ADHD and mood disorders.

Keywords: ADHD; autism; depression; gender; schizophrenia.

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Conflict of interest statement

CONFLICTS OF INTEREST

There is no conflict of interest.

Figures

Figure 1
Figure 1. A schematic of the sex chromosomes with several adjacent genes that have been associated with psychiatric diseases
See this image and copyright information in PMC

References

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