Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2017 Feb:40:65-75.
doi: 10.1016/j.eurpsy.2016.09.003. Epub 2016 Dec 16.

Deconstructing vulnerability for psychosis: Meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk

P Fusar-Poli  1 , M Tantardini  2 , S De Simone  3 , V Ramella-Cravaro  4 , D Oliver  5 , J Kingdon  5 , M Kotlicka-Antczak  6 , L Valmaggia  5 , J Lee  7 , M J Millan  8 , S Galderisi  3 , U Balottin  2 , V Ricca  9 , P McGuire  5
Affiliations
Free article
Meta-Analysis

Deconstructing vulnerability for psychosis: Meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk

P Fusar-Poli et al. Eur Psychiatry. 2017 Feb.
Free article

Abstract

Background: Subjects at ultra high-risk (UHR) for psychosis have an enhanced vulnerability to develop the disorder but the risk factors accounting for this accrued risk are undetermined.

Method: Systematic review of associations between genetic or environmental risk factors for psychosis that are widely established in the literature and UHR state, based on comparisons to controls.

Results: Forty-four studies encompassing 170 independent datasets and 54 risk factors were included. There were no studies on association between genetic or epigenetic risk factors and the UHR state that met the inclusion criteria. UHR subjects were more likely to show obstetric complications, tobacco use, physical inactivity, childhood trauma/emotional abuse/physical neglect, high perceived stress, childhood and adolescent low functioning, affective comorbidities, male gender, single status, unemployment and low educational level as compared to controls.

Conclusions: The increased vulnerability of UHR subjects can be related to environmental risk factors like childhood trauma, adverse life events and affective dysfunction. The role of genetic and epigenetic risk factors awaits clarification.

Keywords: ARMS; Meta-analysis; Prevention; Psychosis; Schizophrenia; UHR.

PubMed Disclaimer