doi: 10.1126/science.2799384.
Detection of cell-affecting agents with a silicon biosensor
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- PMID: 2799384
- DOI: 10.1126/science.2799384
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Detection of cell-affecting agents with a silicon biosensor
Science.
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Abstract
Cellular metabolism is affected by many factors in a cell's environment. Given a sufficiently sensitive method for measuring cellular metabolic rates, it should be possible to detect a wide variety of chemical and physical stimuli. A biosensor has been constructed in which living cells are confined to a flow chamber in which a potentiometric sensor continually measures the rate of production of acidic metabolites. Exploratory studies demonstrate several applications of the device in basic science and technology.
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