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Editorial
. 2016 Nov;43(6):425-427.
doi: 10.1159/000450794. Epub 2016 Nov 2.

Knowledge Is Safety: The Time Is Ripe for Hepatitis E Virus Blood Donor Screening

Tanja Vollmer  1 , Cornelius Knabbe  1 , Jens Dreier  1
Affiliations
Editorial

Knowledge Is Safety: The Time Is Ripe for Hepatitis E Virus Blood Donor Screening

Tanja Vollmer et al. Transfus Med Hemother. 2016 Nov.
No abstract available

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Figures

Fig. 1
Fig. 1
Progression of hepatitis E viremia in seven blood donors with autochthonous HEV genotype 3 infection (modified according to Vollmer et. al [8]). Displayed is the course of HEV-RNA concentration. The day of the detection of HEV-RNA by PCR screening was defined as day 0 [2]. The HEV virus titer in positive plasma samples was quantified using the first WHO international standard for hepatitis E virus RNA for NAT-based assays (Paul Ehrlich Institute, Langen, Germany). The connecting lines for donors 6 and 7 are discontinuous due to a 40-day lack of plasma samples. The grey-shaded background covers the areas of positive donation detected by NAT (pool and ID-NAT) depending on different LODs (95% LOD vs. 50% LOD pool-NAT) [2,18]. The grey-shaded graph represents the course of the extrapolated idealized HEV viremia.
See this image and copyright information in PMC

References

    1. Hewitt PE, Ijaz S, Brailsford SR, Brett R, Dicks S, Haywood B, Kennedy IT, Kitchen A, Patel P, Poh J, Russell K, Tettmar KI, Tossell J, Ushiro-Lumb I, Tedder RS. Hepatitis E virus in blood components: a prevalence and transmission study in southeast England. Lancet. 2014;384:1766–1773. - PubMed
    1. Vollmer T, Diekmann J, Johne R, Eberhardt M, Knabbe C, Dreier J. Novel approach for the detection of hepatitis E virus infection in German blood donors. J Clin Microbiol. 2012;50:2708–2713. - PMC - PubMed
    1. Hogema BM, Molier M, Slot E, Zaaijer HL. Past and present of hepatitis E in the Netherlands. Transfusion. 2014;54:3092–3096. - PMC - PubMed
    1. Kamar N, Dalton HR, Abravanel F, Izopet J. Hepatitis E virus infection. Clin Microbiol Rev. 2014;27:116–138. - PMC - PubMed
    1. Dalton HR, Hazeldine S, Banks M, Ijaz S, Bendall R. Locally acquired hepatitis E in chronic liver disease. Lancet. 2007;369:1260. - PubMed

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