Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Nov;6(1):44-50.
doi: 10.1159/000449344. Epub 2016 Nov 29.

Surgery and Hepatocellular Carcinoma

Nobuhisa Akamatsu  1 , Umberto Cillo  2 , Alessandro Cucchetti  3 , Matteo Donadon  4 , Antonio Daniele Pinna  3 , Guido Torzilli  4 , Norihiro Kokudo  1
Affiliations
Review

Surgery and Hepatocellular Carcinoma

Nobuhisa Akamatsu et al. Liver Cancer. 2016 Nov.

Abstract

The optimal surgical strategy for hepatocellular carcinoma (HCC) is under active debate. Bio-markers of the liver functional reserve as well as volumetric analysis of the future liver remnant are essential for safe liver resection of HCC. The present algorithms applied to surgical strategies for HCC are not ideal because many patients who could potentially undergo safe resection are deemed liver transplant candidates in Western countries, whereas the opposite is the case in Eastern countries. In addition, there is too much focus on expanded criteria for patients with HCC to undergo liver transplantation. The transplantation benefit for patients with HCC should be considered based not only on the individual's benefit, but also on the effect of other patients waiting for LT for other indications.

Keywords: Hepatocellular carcinoma; Liver resection; Liver transplantation.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Modified Barcelona-Clinic Liver Cancer algorithm. TT=tumor thrombus; PS=performance status; M= metastases; N=nodes (lymph nodes); ICG=indocyanine green.
See this image and copyright information in PMC

References

    1. Torzilli G, Makuuchi M, Inoue K, Takayama T, Sakamoto Y, Sugawara Y, Kubota K, Zucchi A. No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our approach. Arch Surg. 1999;134:984–992. - PubMed
    1. Teh SH, Christein J, Donohue J, Que F, Kendrick M, Farnell M, Cha S, Kamath P, Kim R, Nagorney DM. Hepatic resection of hepatocellular carcinoma in patients with cirrhosis: Model of End-Stage Liver Disease (MELD) score predicts perioperative mortality. J Gastrointest Surg. 2005;9:1207–1215. discussion 1215. - PubMed
    1. Cucchetti A, Ercolani G, Vivarelli M, Cescon M, Ravaioli M, La Barba G, Zanello M, Grazi GL, Pinna AD. Impact of model for end-stage liver disease (MELD) score on prognosis after hepatectomy for hepatocellular carcinoma on cirrhosis. Liver Transpl. 2006;12:966–971. - PubMed
    1. Ichikawa T, Uenishi T, Takemura S, Oba K, Ogawa M, Kodai S, Shinkawa H, Tanaka H, Yamamoto T, Tanaka S, Yamamoto S, Hai S, Shuto T, Hirohashi K, Kubo S. A simple, noninvasively determined index predicting hepatic failure following liver resection for hepatocellular carcinoma. J Hepatobiliary Pancreat Surg. 2009;16:42–48. - PubMed
    1. Donadon M, Costa G, Cimino M, Procopio F, Fabbro DD, Palmisano A, Torzilli G. Safe hepatectomy selection criteria for hepatocellular carcinoma patients: a validation of 336 consecutive hepatectomies. The BILCHE score. World J Surg. 2015;39:237–243. - PubMed

LinkOut - more resources