Flawed external validation study of the ADNEX model to diagnose ovarian cancer

B Van Calster¹, E W Steyerberg², T Bourne³, D Timmerman⁴, G S Collins⁵; TG6 of the STRATOS initiative

Affiliations

¹ KU Leuven, Department of Development and Regeneration, Leuven, Belgium; Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.
² Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.
³ KU Leuven, Department of Development and Regeneration, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Queen Charlotte's & Chelsea Hospital, Imperial College London, London, UK.
⁴ KU Leuven, Department of Development and Regeneration, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium.
⁵ Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

PMID: 27995172
PMCID: PMC5154673
DOI: 10.1016/j.gore.2016.09.003

Flawed external validation study of the ADNEX model to diagnose ovarian cancer

B Van Calster et al. Gynecol Oncol Rep. 2016.

. 2016 Sep 14:18:49-50.

doi: 10.1016/j.gore.2016.09.003. eCollection 2016 Nov.

Authors

B Van Calster¹, E W Steyerberg², T Bourne³, D Timmerman⁴, G S Collins⁵; TG6 of the STRATOS initiative

Affiliations

¹ KU Leuven, Department of Development and Regeneration, Leuven, Belgium; Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.
² Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.
³ KU Leuven, Department of Development and Regeneration, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Queen Charlotte's & Chelsea Hospital, Imperial College London, London, UK.
⁴ KU Leuven, Department of Development and Regeneration, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium.
⁵ Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

PMID: 27995172
PMCID: PMC5154673
DOI: 10.1016/j.gore.2016.09.003

No abstract available

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Cited by

ESGO/ISUOG/IOTA/ESGE Consensus Statement on preoperative diagnosis of ovarian tumours.
Timmerman D, Planchamp F, Bourne T, Landolfo C, du Bois A, Chiva L, Cibula D, Concin N, Fischerova D, Froyman W, Gallardo G, Lemley B, Loft A, Mereu L, Morice P, Querleu D, Testa C, Vergote I, Vandecaveye V, Scambia G, Fotopoulou C. Timmerman D, et al. Facts Views Vis Obgyn. 2021 Jun;13(2):107-130. doi: 10.52054/FVVO.13.2.016. Epub 2021 Jun 10. Facts Views Vis Obgyn. 2021. PMID: 34107646 Free PMC article.
ESGO/ISUOG/IOTA/ESGE Consensus Statement on pre-operative diagnosis of ovarian tumors.
Timmerman D, Planchamp F, Bourne T, Landolfo C, du Bois A, Chiva L, Cibula D, Concin N, Fischerova D, Froyman W, Gallardo Madueño G, Lemley B, Loft A, Mereu L, Morice P, Querleu D, Testa AC, Vergote I, Vandecaveye V, Scambia G, Fotopoulou C. Timmerman D, et al. Int J Gynecol Cancer. 2021 Jul;31(7):961-982. doi: 10.1136/ijgc-2021-002565. Epub 2021 Jun 10. Int J Gynecol Cancer. 2021. PMID: 34112736 Free PMC article. Review.
Response to letter to the editor concerning validation of IOTA ADNEX model.
Szubert S, Wojtowicz A, Zywica P. Szubert S, et al. Gynecol Oncol Rep. 2016 Nov 1;18:51-52. doi: 10.1016/j.gore.2016.10.009. eCollection 2016 Nov. Gynecol Oncol Rep. 2016. PMID: 27995173 Free PMC article. No abstract available.
ECO-SCORE: Development of a New Ultrasound Score for the Study of Cystic and Solid-Cystic Adnexal Masses Based on Imaging Characteristics.
Rodríguez-Rubio C, Vegas-Viedma S, Del Olmo-Reillo M, Quintana-Zapata P, Sancho-Sauco J, Pablos-Antona MJ, Alcázar JL, Pelayo-Delgado I. Rodríguez-Rubio C, et al. Biomedicines. 2025 Jan 29;13(2):317. doi: 10.3390/biomedicines13020317. Biomedicines. 2025. PMID: 40002730 Free PMC article.

References

1. Altman D.G., Vergouwe Y., Royston P., Moons K.G. Prognosis and prognostic research: validating a prognostic model. BMJ. 2009;338:b605. - PubMed
1. Collins G.S., Ogundimu E.O., Altman D.G. Sample size considerations for the external validation of a multivariable prognostic model: a resampling study. Stat. Med. 2016;35:214–226. - PMC - PubMed
1. Moons K.G., Altman D.G., Reitsma J.B., Ioannidis J.P., Macaskill P., Steyerberg E.W. Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): explanation and elaboration. Ann. Intern. Med. 2015;162:W1–73. - PubMed
1. Riley R.D., Ensor J., Snell K.I., Debray T.P., Altman D.G., Moons K.G. External validation of clinical prediction models using big datasets from e-health records or IPD meta-analysis: opportunities and challenges. BMJ. 2016;353:i3140. - PMC - PubMed
1. Steyerberg E.W. Springer-Verlag; New York: 2009. Clinical Prediction Models. A Practical Approach to Development, Validation, and Updating.

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Flawed external validation study of the ADNEX model to diagnose ovarian cancer

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Flawed external validation study of the ADNEX model to diagnose ovarian cancer

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