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. 2017 Dec;58(12):703-707.
doi: 10.11622/smedj.2016189. Epub 2016 Dec 20.

Interval increase in the prevalence of symptomatic cholelithiasis-associated non-alcoholic fatty liver disease over a ten-year period in an Asian population

Kevin Beng Chin Khaw  1 , Rachel Huiyi Choi  1 , Juinn Huar Kam  2 , Bibhas Chakraborty  3 , Pierce Kah Hoe Chow  2   3   4
Affiliations

Interval increase in the prevalence of symptomatic cholelithiasis-associated non-alcoholic fatty liver disease over a ten-year period in an Asian population

Kevin Beng Chin Khaw et al. Singapore Med J. 2017 Dec.

Abstract

Introduction: Non-alcoholic fatty liver disease (NAFLD) is frequently associated with cholelithiasis. The prevalence of NAFLD in Asia has been on the rise, but the magnitude of this increase had not been studied previously.

Methods: A retrospective cohort study was conducted on consecutive patients who underwent laparoscopic or open cholecystectomy from November 2001 to November 2004 (Cohort 1) and from November 2011 to November 2014 (Cohort 2) at Singapore General Hospital. Preoperative diagnostic scans (e.g. ultrasonography, computed tomography and magnetic resonance imaging) and clinical data were reviewed for the presence of fatty liver. Statistical analysis was performed.

Results: In Cohorts 1 and 2, 127 patients and 99 patients were operated on, respectively. Cohort 2 had significantly higher proportions of patients with NAFLD (56.6% vs. 40.2%; p < 0.015) and hyperlipidaemia (45.5% vs. 18.9%; p < 0.001) as compared to Cohort 1. Binary logistic regression analysis showed that hypertension (odds ratio [OR] 2.558; p < 0.004) and Indian ethnicity (OR 5.448; p < 0.043) were significantly associated with NAFLD.

Conclusion: Similar to other international studies, we found a significant increase in the prevalence of patients with NAFLD presenting symptomatically for cholecystectomy over an interval of ten years in Singapore. Hypertension and Indian ethnicity were significantly associated with NAFLD in both time periods. This trend supports the need for concerted public health intervention to stem the increasing incidence of NAFLD and prevent its progression to more advanced liver disease.

Keywords: Asian; Singapore; cholelithiasis; epidemiology; non-alcoholic fatty liver disease.

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Figures

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Box 1
Inclusion and exclusion criteria for patient enrolment:
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Demographic, medical and lifestyle characteristics retrieved:
See this image and copyright information in PMC

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