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. 2017 Jan 6;19(1):62-65.
doi: 10.1021/acs.orglett.6b03336. Epub 2016 Dec 20.

Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors

Preeti Chauhan  1 , Prerona Bora  1 , Govindan Ravikumar  1 , Swetha Jos  1 , Harinath Chakrapani  1
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Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors

Preeti Chauhan et al. Org Lett. .

Abstract

Hydrogen sulfide (H2S) is a mediator of a number of cellular processes, and modulating cellular levels of this gas has emerged as an important therapeutic area. Localized generation of H2S is thus very useful but highly challenging. Here, we report pivaloyloxymethyl-based carbonothioates and carbamothioates that are activated by the enzyme, esterase, to generate carbonyl sulfide (COS), which is hydrolyzed to H2S.

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