Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Oct 2;6(4):51-53.
doi: 10.1080/19381956.2016.1241373.

Lost in translation? Microchimersim detection in experimental and clinical transplantation

Jhade D Woodall  1 , Mehmet C Uluer, Matthew T Chrencik, Arthur J Nam, Stephen T Bartlett, Rolf N Barth
Affiliations
Review

Lost in translation? Microchimersim detection in experimental and clinical transplantation

Jhade D Woodall et al. Chimerism. .

Abstract

The importance of further elucidating the properties surrounding microchimerism in various experi- mental models and clinical transplantation are limited by current techniques and the sensitivity of available platforms. Development of reliable methods and use routine use of microchimerism detection in clinical practice could guide clinical decision making regarding rejection, stable function, and tolerance.

Keywords: microchimerism; next generation sequencing, PCR; transplantation.

PubMed Disclaimer

References

    1. Kawai T, et al.. Long-term results in recipients of combined HLA-mismatched kidney and bone marrow transplantation without maintenance immunosuppression. Am J Transplant 2014; 14(7): 1599-611; PMID:24903438; http://dx.doi.org/10.1111/ajt.12731 - DOI - PMC - PubMed
    1. Leventhal J, et al.. Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Sci Transl Med 2012; 4(124): 124ra28; PMID:22399264; http://dx.doi.org/10.1126/scitranslmed.3003509 - DOI - PMC - PubMed
    1. Scandling JD, et al.. Chimerism, graft survival, and withdrawal of immunosuppressive drugs in HLA matched and mismatched patients after living donor kidney and hematopoietic cell transplantation. Am J Transplant 2015; 15(3): 695-704; PMID:25693475; http://dx.doi.org/10.1111/ajt.13091 - DOI - PubMed
    1. Barth RN, et al.. Vascularized bone marrow-based immunosuppression inhibits rejection of vascularized composite allografts in nonhuman primates. Am J Transplant 2011; 11(7): 1407-16; PMID:21668624; http://dx.doi.org/10.1111/j.1600-6143.2011.03551.x - DOI - PubMed
    1. Schultz BD, et al.. Early microchimerism after face transplantation detected by quantitative real-time polymerase chain reaction of insertion/deletion polymorphisms. Transplantation 2015; 99(7): e44-5; PMID:26147136; http://dx.doi.org/10.1097/TP.0000000000000745 - DOI - PubMed

LinkOut - more resources