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Meta-Analysis
. 2016 Dec 20;11(12):e0168691.
doi: 10.1371/journal.pone.0168691. eCollection 2016.

Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis

Zhongju Shi  1 , Hengxing Zhou  1 , Bin Pan  1 , Lu Lu  1 , Jun Liu  1 , Yi Kang  1 , Xue Yao  1 , Shiqing Feng  1
Affiliations
Meta-Analysis

Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis

Zhongju Shi et al. PLoS One. .

Abstract

Purpose: Nowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn't come to an agreement. This meta-analysis was conducted to evaluate the effectiveness of teriparatide for fracture healing.

Methods: We searched PubMed, the Cochrane Library, and Embase in August 2016 for randomized controlled trials (RCTs) which concerned the treatment of teriparatide for fracture healing.

Results: Finally, a total of 380 patients were randomly assigned in the 5 trials included in this meta-analysis. There was a significant effectiveness with regards to function improvement in patients following fracture, however, there was no significant effectiveness with regards to time of radiographic fracture healing, fracture healing rate and reduction in pain.

Conclusions: This analysis showed that administration of teriparatide following fracture lacked the effectiveness for fracture healing. Moreover, teriparatide administration had no apparent adverse effects. These results should be interpreted with caution because of some clear limitations. If we want to confirm whether teriparatide improves fracture healing, more high-quality randomized controlled trials are needed.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of selection of studies.
Fig 2
Fig 2. Risk of bias summary.
The red with a minus means high risk of bias; the yellow with a question mark means unclear; the green with a plus means low risk of bias.
Fig 3
Fig 3. Forest plot for radiological fracture healing time.
Fig 4
Fig 4. Forest plot for radiological fracture healing rate.
Fig 5
Fig 5. Forest plot for radiological fracture pain degree.
Fig 6
Fig 6. Forest plot for radiological fracture functional outcome.
See this image and copyright information in PMC

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References

    1. Einhorn TA, Gerstenfeld LC. Fracture healing: mechanisms and interventions. Nature reviews Rheumatology. 2015;11(1):45–54. PubMed Central PMCID: PMC4464690. 10.1038/nrrheum.2014.164 - DOI - PMC - PubMed
    1. Bishop GB, Einhorn TA. Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery. International orthopaedics. 2007;31(6):721–7. PubMed Central PMCID: PMC2266667. 10.1007/s00264-007-0424-8 - DOI - PMC - PubMed
    1. Hankenson KD, Gagne K, Shaughnessy M. Extracellular signaling molecules to promote fracture healing and bone regeneration. Advanced drug delivery reviews. 2015;94:3–12. 10.1016/j.addr.2015.09.008 - DOI - PubMed
    1. Moreau PG. Book review: Rockwood and Green's fractures in adults. Annals of Saudi medicine. 1994;14(1):75.
    1. Phillips AM. Overview of the fracture healing cascade. Injury. 2005;36 Suppl 3:S5–7. - PubMed