Hippo Wades into Cancer Immunology

Abstract

The Hippo pathway limits organ size and suppresses tumors. Reporting in Cell, Moroishi et al. (2016), show that, paradoxically, Hippo pathway inactivation can repress tumor growth by modulating tumor immunogenicity. This could explain the rarity of pathway mutations in cancers and suggests Hippo pathway repression as a cancer immunotherapy modality.