Kinetics of tissue penetration. Are high plasma peak concentrations or sustained levels preferable for effective antibiotic therapy?

Abstract

The experimental evidence and the theory of antibiotic transport into peripheral foci of infection have been discussed. Support is presented in favour of the concept that intermittent dosage with peak concentrations of sufficient size would seem preferable. The duration of plasma concentrations above certain thresholds is a basic requirement for successful antimicrobial therapy.