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. 2017 Mar;60(3):333-339.
doi: 10.1016/j.jadohealth.2016.10.015. Epub 2016 Dec 18.

Anti-Müllerian Hormone in Obese Adolescent Girls With Polycystic Ovary Syndrome

Joon Young Kim  1 , Hala Tfayli  2 , Sara F Michaliszyn  3 , SoJung Lee  1 , Alexis Nasr  1 , Silva Arslanian  4
Affiliations

Anti-Müllerian Hormone in Obese Adolescent Girls With Polycystic Ovary Syndrome

Joon Young Kim et al. J Adolesc Health. 2017 Mar.

Abstract

Purpose: Anti-Müllerian hormone (AMH) is proposed as a biomarker of polycystic ovary syndrome (PCOS). This study investigated: (1) AMH concentrations in obese adolescents with PCOS versus without PCOS; (2) the relationship of AMH to sex steroid hormones, adiposity, and insulin resistance; and (3) the optimal AMH value and the multivariable prediction model to determine PCOS in obese adolescents.

Methods: AMH levels were measured in 46 obese PCOS girls and 43 obese non-PCOS girls. Sex steroid hormones, clamp-measured insulin sensitivity and secretion, body composition, and abdominal adiposity were evaluated. Logistic regression and receiver-operating characteristic curve analyses were used, and multivariate prediction models were developed to test the utility of AMH for the diagnosis of PCOS.

Results: AMH levels were higher in obese PCOS versus non-PCOS girls (8.3 ± .6 vs. 4.3 ± .4 ng/mL, p < .0001), of comparable age and puberty. AMH concentrations correlated positively with age in both groups, total and free testosterone in PCOS girls only, abdominal adipose tissue in non-PCOS girls, with no correlation to in vivo insulin sensitivity and secretion in either groups. A multivariate model including AMH (cutoff 6.26 ng/mL, area under the curve .788) together with sex hormone-binding globulin and total testosterone exhibited 93.4% predictive power for diagnosing PCOS.

Conclusions: AMH may be a useful biomarker for the diagnosis of PCOS in obese adolescent girls.

Keywords: AMH; Hyperandrogenemia; Obese adolescents; PCOS.

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Figures

Figure 1
Figure 1
Serum AMH concentrations in obese adolescent girls with PCOS vs. without PCOS. Data were presented as mean ± SEM. Adjusted P is for race, glycemic status, BMI and fat mass.
Figure 2
Figure 2
Relationship of AMH to age (Panel A), total and free testosterone (Panels B & C), and total abdominal adipose tissue (Panel D) in obese PCOS (Left Panel) and obese non-PCOS adolescent girls (Right panel). NS, not-significant.
See this image and copyright information in PMC

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