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. 2017 Feb:15:81-89.
doi: 10.1016/j.ebiom.2016.11.031. Epub 2016 Dec 1.

Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment

Chung-Feng Huang  1 , Cing-Yi Huang  2 , Ming-Lun Yeh  3 , Shu-Chi Wang  2 , Kuan-Yu Chen  2 , Yu-Min Ko  2 , Ching-Chih Lin  2 , Yi-Shan Tsai  2 , Pei-Chien Tsai  2 , Zu-Yau Lin  3 , Shinn-Cherng Chen  3 , Chia-Yen Dai  4 , Jee-Fu Huang  3 , Wan-Long Chuang  3 , Ming-Lung Yu  5
Affiliations

Genetics Variants and Serum Levels of MHC Class I Chain-related A in Predicting Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients Post Antiviral Treatment

Chung-Feng Huang et al. EBioMedicine. 2017 Feb.

Erratum in

Abstract

Background/aims: The genome-wide association study has shown that MHC class I chain-related A (MICA) genetic variants were associated with hepatitis C virus (HCV) related hepatocellular carcinoma (HCC). The impact of the genetic variants and its serum levels on post-treatment cohort is elusive [corrected].

Methods: MICA rs2596542 genotype and serum MICA (sMICA) levels were evaluated in 705 patients receiving antiviral therapy.

Results: Fifty-eight (8·2%) patients developed HCC, with a median follow-up period of 48·2 months (range: 6–129 months). The MICA A allele was associated with a significantly increased risk of HCC development in cirrhotic non-SVR patients but not in patients of non-cirrhotic and/or with SVR. For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26·38, P = 0·002) [corrected] and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development. The risk A allele or GG genotype with sMICA > 175 ng/mL provided the best accuracy (79%) and a negative predictive value of 100% in predicting HCC.

Conclusions: Cirrhotic patients who carry MICA risk alleles and those without risk alleles but with high sMICA levels possessed the highest risk of HCC development once they failed antiviral therapy.

Keywords: EGF; HCC; IL-28; MICA; PNPLA3; SNP; SVR; Treatment; sMICA.

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Figures

Fig. 1
Fig. 1
Flow chart of the patients.
Fig. 2
Fig. 2
Association of MICA rs2596542 genotype with HCC development stratified by the SVR and cirrhotic status. Risk allele: AA + AG genotype. Non-A allele: GG genotype.
Fig. 3
Fig. 3
sMICA levels in patients with or without HCC development stratified by SVR status.
Fig. 4
Fig. 4
sMICA levels of different MICA SNPs among LC non-SVR patients with or without HCC.
Fig. 5
Fig. 5
HCC development in non-SVR LC patients with different MICA SNP and sMICA levels.
See this image and copyright information in PMC

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