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Case Reports
. 2016 Sep;7(4):120-122.
doi: 10.4103/0976-0105.189436.

Carbamazepine-induced angioedema

Ansha Subramanian  1 , Mangaiarkkarasi Adhimoolam  1 , Senthil Gopalakrishnan  1 , Meher Ali Rajamohammed  1
Affiliations
Case Reports

Carbamazepine-induced angioedema

Ansha Subramanian et al. J Basic Clin Pharm. 2016 Sep.

Abstract

Angioedema is a rare adverse reaction of carbamazepine, which causes localized tissue edema in submucosal and subcutaneous tissue mediated by histamine, serotonin, and kinins (bradykinin). We report a case of 34-year-old female who developed angioedema, 24 h after administration of carbamazepine for treating bipolar disorder. Patient's symptoms responded rapidly with antihistamine therapy and with the withdrawal of carbamazepine, the offending drug. Carbamazepine-induced angioedema is a life-threatening reaction which requires immediate treatment and monitoring in order to avoid morbidity and mortality.

Keywords: Angioedema; antiepileptic drug; carbamazepine; cutaneous reaction.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Patient with angioedema showing swelling of both lips, (b) after recovery from angioedema
See this image and copyright information in PMC

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