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. 2016:2016:6725913.
doi: 10.1155/2016/6725913. Epub 2016 Nov 24.

Peripheral Giant Cell Granuloma in a Child Associated with Ectopic Eruption and Traumatic Habit with Control of Four Years

Luiz Evaristo Ricci Volpato  1 , Cristhiane Almeida Leite  2 , Brunna Haddad Anhesini  3 , Jéssica Marques Gomes da Silva Aguilera  4 , Álvaro Henrique Borges  1
Affiliations

Peripheral Giant Cell Granuloma in a Child Associated with Ectopic Eruption and Traumatic Habit with Control of Four Years

Luiz Evaristo Ricci Volpato et al. Case Rep Dent. 2016.

Abstract

Peripheral giant cell granuloma (PGCG) is a nonneoplastic lesion that may affect any region of the gingiva or alveolar mucosa of edentulous and toothed areas, preferentially in the mandible and rarely occurring in children. This report describes the clinical and histopathological findings of a PGCG diagnosed in the maxilla of a 9-year-old boy associated with a tooth erupting improperly and a traumatic habit. The patient did not present anything noteworthy on extraoral physical examination or medical history, but the habit of picking his teeth and "poking" the gingiva. The oral lesion consisted of an asymptomatic, rounded, pink colored, smooth surface, soft tissue injury with fibrous consistency and approximated size of 1.5 cm located in the attached gingiva between the upper left permanent lateral incisor and the primary canine of the same side. Excisional biopsy was performed through curettage and removal of the periosteum, periodontal ligament, and curettage of the involved teeth with vestibular access. The histopathological analysis led to the diagnosis of PGCG. The prompt diagnosis and treatment of the PGCG resulted in a more conservative surgery and a reduced risk for tooth and bone loss and recurrence of the lesion. After four years of control, patient had no relapse of the lesion and good gingival and osseous health.

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Conflict of interest statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

Figures

Figure 1
Figure 1
Nodular lesion between the upper left permanent lateral incisor and the primary canine.
Figure 2
Figure 2
Radiographic aspect of the lesion without signs of abnormality.
Figure 3
Figure 3
Clinical aspect after excisional biopsy of the lesion.
Figure 4
Figure 4
(a) Low magnification of PGCG. The stratified squamous epithelium exhibits hyperkeratosis and acanthosis. The subjacent fibrous connective tissue showed noncapsulated nodular proliferation of cellular mesenchymal tissue with abundant multinucleated giant cells dispersed throughout (H&E; original magnification ×20). (b) Higher magnification of PGCG showing giant cells, spindle-shaped ovoid plump stromal cells, inflammatory cells, capillaries, hemorrhage, and hemosiderophages (H&E; original magnification ×400).
Figure 5
Figure 5
Seven-day control.
Figure 6
Figure 6
Clinical appearance after four years.
Figure 7
Figure 7
Radiographic control after four years without signs of abnormality.
See this image and copyright information in PMC

References

    1. Jaffe H. L. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surgery, Oral Medicine, Oral Pathology. 1953;6(1):159–175. doi: 10.1016/0030-4220(53)90151-0. - DOI - PubMed
    1. Lester S. R., Cordell K. G., Rosebush M. S., Palaiologou A. A., Maney P. Peripheral giant cell granulomas: a series of 279 cases. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014;118(4):475–482. doi: 10.1016/j.oooo.2014.06.004. - DOI - PubMed
    1. Shadman N., Ebrahimi S. F., Jafari S., Eslami M. Peripheral giant cell granuloma: a review of 123 cases. Dental Research Journal. 2009;6(1):47–50. - PMC - PubMed
    1. Mighell A. J., Robinson P. A., Hume W. J. Peripheral giant cell granuloma: a clinical study of 77 cases from 62 patients, and literature review. Oral Diseases. 1995;1(1):12–19. - PubMed
    1. Chaparro Avendaño A. V., Berini Aytés L., Gay Escoda C. Peripheral giant cell granuloma. A report of five cases and review of the literature. Medicina Oral, Patologia Oral y Cirugia Bucal. 2005;10(1):48–57. - PubMed

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