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Review
. 2016 Dec;95(51):e5080.
doi: 10.1097/MD.0000000000005080.

A case report and literature review of Churg-Strauss syndrome presenting with myocarditis

Lu Qiao  1 , Dengfeng Gao
Affiliations
Review

A case report and literature review of Churg-Strauss syndrome presenting with myocarditis

Lu Qiao et al. Medicine (Baltimore). 2016 Dec.

Abstract

Background: Churg-Strauss syndrome (CSS) is a multisystem disorder characterized by asthma, prominent peripheral blood eosinophilia, and vasculitis signs.

Case summary: Here we report a case of CSS presenting with acute myocarditis and heart failure and review the literature on CSS with cardiac involvement. A 59-year-old man with general fatigue, numbness of limbs, and a 2-year history of asthma was admitted to the department of orthopedics. Eosinophilia, history of asthma, lung infiltrates, peripheral neurological damage, and myocarditis suggested the diagnosis of CSS. Transthoracic echocardiography revealed a dilated hypokinetic left ventricle (left ventricular ejection fraction ∼40%) with mild segmental abnormalities in the septal and apical segments.

Conclusion: By reviewing the present case reports, we concluded that (1) the younger age of CSS, the greater occurrence rate of complicating myocarditis and the poorer prognosis; (2) female CSS patients are older than male patients; (3) patients with cardiac involvement usually have a history of severe asthma; (4) markedly increased eosinophil count suggests a potential diagnosis of CSS (when the count increases to 20% of white blood cell counts or 8.1 × 109/L, eosinophils start to infiltrate into myocardium); and (5) negative ANCA status is associated with heart disease in CSS.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Electrocardiography of a 59-year-old man with general fatigue, numbness of limbs, and a 2-year history of asthma.
Figure 2
Figure 2
Coronary CT angiography of our case. CT = computed tomography.
See this image and copyright information in PMC

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