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Practice Guideline
. 2017 Aug;102(2):213-218.
doi: 10.1002/cpt.598. Epub 2017 Apr 6.

Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron

G C Bell  1 , K E Caudle  2 , M Whirl-Carrillo  3 , R J Gordon  4 , K Hikino  5 , C A Prows  6 , A Gaedigk  7 , Jag Agundez  8   9 , S Sadhasivam  10   11 , T E Klein  3 , M Schwab  12   13   14
Affiliations
Practice Guideline

Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron

G C Bell et al. Clin Pharmacol Ther. 2017 Aug.

Abstract

5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are used in the prevention of chemotherapy- induced, radiation-induced and postoperative nausea and vomiting. CYP2D6 polymorphisms can influence the metabolism of some of these drugs (i.e. ondansetron and tropisetron) thereby affecting drug efficacy. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for ondansetron and tropisetron based on CYP2D6 genotype (updates at www.pharmgkb.org).

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Conflict of interest statement

CONFLICT OF INTEREST

All other authors declare no conflicts of interest.

References

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