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Comment
. 2016 Dec 20;45(6):1177-1179.
doi: 10.1016/j.immuni.2016.12.003.

One Niche to Rule Both Maintenance and Loss of Stemness in HSCs

Motonari Kondo  1
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One Niche to Rule Both Maintenance and Loss of Stemness in HSCs

Motonari Kondo. Immunity. .
Free article

Abstract

Hemato-lymphopoiesis initiated by hematopoietic stem cells (HSCs) is tightly regulated by factors present in the bone marrow (BM) niche. Using genetically modified mice, Gomes et al. (2016) show that IL-7 is produced by HSC niche-forming cells and find that the same niche that controls HSC self-renewal can also support differentiation.

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