Sifting through CD8+ T Cell Memory
- PMID: 28002725
- DOI: 10.1016/j.immuni.2016.12.005
Sifting through CD8+ T Cell Memory
Abstract
In this issue of Immunity, Gerlach et al. (2016) describe three distinct memory CD8+ T cell subsets based upon expression of the fractalkine receptor CX3CR1. Their findings revise the paradigm of effector and central memory T cells by revealing a subset of CD8+ memory T cells defined by intermediate levels of expression of CX3CR1 that conducts tissue surveillance.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment on
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The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis.Immunity. 2016 Dec 20;45(6):1270-1284. doi: 10.1016/j.immuni.2016.10.018. Epub 2016 Dec 6. Immunity. 2016. PMID: 27939671 Free PMC article.
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