The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

doi:10.1017/cjn.2016.415

Observational Study

. 2017 Mar;44(2):196-202.

doi: 10.1017/cjn.2016.415. Epub 2016 Dec 22.

The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

Sali M K Farhan¹, Robert Bartha², Sandra E Black³, Dale Corbett⁴, Elizabeth Finger⁵, Morris Freedman⁶, Barry Greenberg⁷, David A Grimes⁸, Robert A Hegele¹, Chris Hudson⁹, Peter W Kleinstiver¹⁰, Anthony E Lang¹¹, Mario Masellis³, William E McIlroy¹², Paula M McLaughlin¹⁰, Manuel Montero-Odasso¹³, David G Munoz¹⁴, Douglas P Munoz¹⁵, Stephen Strother¹⁶, Richard H Swartz¹⁷, Sean Symons¹⁸, Maria Carmela Tartaglia¹⁹, Lorne Zinman³; ONDRI Investigators; Michael J Strong²

Affiliations

¹ 1Department of Biochemistry,Schulich School of Medicine & Dentistry,Western University,London,Canada.
² 2Robarts Research Institute,Western University,London,Canada.
³ 4Department of Medicine (Neurology),Sunnybrook Health Sciences Centre,LC Campbell Cognitive Neurology Research Unit,Hurvitz Brain Science Research Program,Sunnybrook Research Institute,University of Toronto,Toronto,Canada.
⁴ 6Department of Cellular and Molecular Medicine, Faculty of Medicine,University of Ottawa,Ottawa,Canada.
⁵ 7Department of Clinical Neurological Sciences,Schulich School of Medicine & Dentistry,Western University,London,Canada.
⁶ 8Department of Medicine (Neurology),Baycrest Health Sciences and University of Toronto,Toronto,Ontario,Canada.
⁷ 10Toronto Dementia Research Alliance,University Health Network,Toronto,Canada.
⁸ 11Department of Medicine,The Ottawa Hospital, Faculty of Medicine,University of Ottawa,Ottawa,Canada.
⁹ 12School of Optometry & Vision Science,University of Waterloo,Waterloo,Canada.
¹⁰ 13Schulich School of Medicine & Dentistry,Western University,London,Canada.
¹¹ 14Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease,Toronto Western Hospital and the Department of Medicine,University of Toronto,Toronto,Canada.
¹² 15Department of Kinesiology,University of Waterloo,Waterloo,Canada.
¹³ 16Gait and Brain Lab,Department of Medicine (Geriatrics) and Epidemiology and Biostatistics,Schulich School of Medicine & Dentistry,London,Canada.
¹⁴ 17Keenan Research Centre for Biomedical Science of St. Michael's Hospital,Laboratory Medicine and Pathobiology,University of Toronto,Division of Pathology,St. Michael's Hospital,Toronto,Canada.
¹⁵ 18Centre for Neuroscience Studies,Queen's University,Kingston,Canada.
¹⁶ 19Rotman Research Institute,Baycrest,Department of Medical Biophysics,University of Toronto,Toronto,Canada.
¹⁷ 20Department of Medicine (Neurology),L.C. Campbell Cognitive Neurology Research Unit,Hurvitz Brain Science Research Program,Sunnybrook Research Institute,Sunnybrook Health Sciences Centre,Institute of Medical Science, Faculty of Medicine,University of Toronto,Toronto,Canada.
¹⁸ 21Department of Medical Imaging,Sunnybrook Health Sciences Centre,Toronto,Canada.
¹⁹ 22Division of Neurology and Department of Medicine,University of Toronto. Tanz Centre for Research in Neurodegenerative Diseases,University of Toronto,Toronto,Canada.

PMID: 28003035
DOI: 10.1017/cjn.2016.415

Observational Study

The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

Sali M K Farhan et al. Can J Neurol Sci. 2017 Mar.

. 2017 Mar;44(2):196-202.

doi: 10.1017/cjn.2016.415. Epub 2016 Dec 22.

Authors

Affiliations

¹ 1Department of Biochemistry,Schulich School of Medicine & Dentistry,Western University,London,Canada.
² 2Robarts Research Institute,Western University,London,Canada.
³ 4Department of Medicine (Neurology),Sunnybrook Health Sciences Centre,LC Campbell Cognitive Neurology Research Unit,Hurvitz Brain Science Research Program,Sunnybrook Research Institute,University of Toronto,Toronto,Canada.
⁴ 6Department of Cellular and Molecular Medicine, Faculty of Medicine,University of Ottawa,Ottawa,Canada.
⁵ 7Department of Clinical Neurological Sciences,Schulich School of Medicine & Dentistry,Western University,London,Canada.
⁶ 8Department of Medicine (Neurology),Baycrest Health Sciences and University of Toronto,Toronto,Ontario,Canada.
⁷ 10Toronto Dementia Research Alliance,University Health Network,Toronto,Canada.
⁸ 11Department of Medicine,The Ottawa Hospital, Faculty of Medicine,University of Ottawa,Ottawa,Canada.
⁹ 12School of Optometry & Vision Science,University of Waterloo,Waterloo,Canada.
¹⁰ 13Schulich School of Medicine & Dentistry,Western University,London,Canada.
¹¹ 14Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease,Toronto Western Hospital and the Department of Medicine,University of Toronto,Toronto,Canada.
¹² 15Department of Kinesiology,University of Waterloo,Waterloo,Canada.
¹³ 16Gait and Brain Lab,Department of Medicine (Geriatrics) and Epidemiology and Biostatistics,Schulich School of Medicine & Dentistry,London,Canada.
¹⁴ 17Keenan Research Centre for Biomedical Science of St. Michael's Hospital,Laboratory Medicine and Pathobiology,University of Toronto,Division of Pathology,St. Michael's Hospital,Toronto,Canada.
¹⁵ 18Centre for Neuroscience Studies,Queen's University,Kingston,Canada.
¹⁶ 19Rotman Research Institute,Baycrest,Department of Medical Biophysics,University of Toronto,Toronto,Canada.
¹⁷ 20Department of Medicine (Neurology),L.C. Campbell Cognitive Neurology Research Unit,Hurvitz Brain Science Research Program,Sunnybrook Research Institute,Sunnybrook Health Sciences Centre,Institute of Medical Science, Faculty of Medicine,University of Toronto,Toronto,Canada.
¹⁸ 21Department of Medical Imaging,Sunnybrook Health Sciences Centre,Toronto,Canada.
¹⁹ 22Division of Neurology and Department of Medicine,University of Toronto. Tanz Centre for Research in Neurodegenerative Diseases,University of Toronto,Toronto,Canada.

PMID: 28003035
DOI: 10.1017/cjn.2016.415

Abstract

Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.

Keywords: Alzheimer’s; Amyotrophic Lateral Sclerosis; Dementia; Frontotemporal Dementia; Neurodegeneration; Parkinson Disease; vascular cognitive impairment.

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The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

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The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

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