Pancreatic cancer: Pancreatic carcinogenesis - several small steps or one giant leap?

Affiliations

¹ Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts 02138, USA.
² Human Oncology and Pathogenesis Program, Department of Pathology, David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

Comment

Johannes G Reiter et al. Nat Rev Gastroenterol Hepatol. 2016.

. 2016 Dec 22;14(1):7-8.

doi: 10.1038/nrgastro.2016.190.

¹ Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts 02138, USA.
² Human Oncology and Pathogenesis Program, Department of Pathology, David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns.
Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson GW, Connor AA, Denroche RE, Liang SB, Brown AM, Kim JC, Wang T, Simpson JT, Beck T, Borgida A, Buchner N, Chadwick D, Hafezi-Bakhtiari S, Dick JE, Heisler L, Hollingsworth MA, Ibrahimov E, Jang GH, Johns J, Jorgensen LG, Law C, Ludkovski O, Lungu I, Ng K, Pasternack D, Petersen GM, Shlush LI, Timms L, Tsao MS, Wilson JM, Yung CK, Zogopoulos G, Bartlett JM, Alexandrov LB, Real FX, Cleary SP, Roehrl MH, McPherson JD, Stein LD, Hudson TJ, Campbell PJ, Gallinger S. Notta F, et al. Nature. 2016 Oct 20;538(7625):378-382. doi: 10.1038/nature19823. Epub 2016 Oct 12. Nature. 2016. PMID: 27732578 Free PMC article.