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. 2017 Aug;31(16):1930-1934.
doi: 10.1080/14786419.2016.1261343. Epub 2016 Dec 22.

Chemical constituents and antileukemic activity of Eugenia dysenterica

Renan Vitek  1 , Leice M R de Novais  1 , Heron F V Torquato  2 , Edgar J Paredes-Gamero  2   3 , Mário G de Carvalho  4 , Paulo T de Sousa Jr  1 , Marcos J Jacinto  1 , Virgínia C da Silva  1
Affiliations

Chemical constituents and antileukemic activity of Eugenia dysenterica

Renan Vitek et al. Nat Prod Res. 2017 Aug.

Abstract

The study about Eugenia dysenterica led to the isolation of 3-acetyl-urs-12-en-28-oic (1), 3-acetyl-olean-12-en-28-oic acid (2) and isoquercetin (3) from the stem barks, and of 3-O-β-glucopyranosyl-β-sitosterol (4), methyl 3-hydroxy-4-methoxybenzoate (5), methyl 4-hydroxyphenyl propionate (6), E-methyl-4-hydroxycinnamate (7), quercetin-3-O-(6ꞌꞌ-O-galloyl)-β-d-glucopyranoside (8) and quercetin-3-O-β-d-galactopyranoside (9) from the leaves. The structures 1-9 were set through the analysis of their NMR spectroscopic data. Compounds 2, 3 and 5-8 were reported for the first time in the Eugenia genus. Compound 8 reduced cell viability and presented IC50 values 40.3 and 36.7 μM, for the CCRF-CEM and the Kasumi-1 cells, respectively.

Keywords: Eugenia dysenterica; cell cycle arrest; cell death; cell differentiation; galloyl flavonol; leukemia.

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