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Review
. 2016 Dec 22:6:39672.
doi: 10.1038/srep39672.

Osteoarthritis and the risk of cardiovascular disease: a meta-analysis of observational studies

Haoran Wang  1 , Jing Bai  2 , Bing He  3 , Xinrong Hu  1 , Dongliang Liu  1
Affiliations
Review

Osteoarthritis and the risk of cardiovascular disease: a meta-analysis of observational studies

Haoran Wang et al. Sci Rep. .

Abstract

Previous observational studies have suggested a potential relationship between osteoarthritis (OA) and the risk of cardiovascular disease (CVD), with conflicting results. We aimed to provide a systematic and quantitative summary of the association between OA and the risk of CVD. We searched Medline and EMBASE to retrieve prospective and retrospective studies that reported risk estimates of the association between OA status and CVD risk. Pooled estimates were calculated by a random effects model. The search yielded 15 articles including a total of 358,944 participants, including 80,911 OA patients and 29,213 CVD patients. Overall, the risk of CVD was significantly increased by 24% (RR: 1.24, 95% CI: 1.12 to 1.37, P < 0.001) in patients with OA compared with the general population, with no significant publication bias. Furthermore, sensitivity analysis indicated that our results were robust and were not influenced by any one study. In conclusion, this meta-analysis provides strong evidence that OA is a significant risk factor for CVD.

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Figures

Figure 1
Figure 1. Literature Search for the Meta-analysis.
Figure 2
Figure 2. Association between OA and CVD risk.
Estimates are derived from random effects. Dots indicate relative risks. Horizontal lines indicate 95% confidence intervals for relative risks. Diamonds represent pooled relative risk estimates with 95% confidence intervals.
See this image and copyright information in PMC

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