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Comparative Study
. 2016 Nov/Dec;45(7):E439-E443.

Comparing Cost, Efficacy, and Safety of Intravenous and Topical Tranexamic Acid in Total Hip and Knee Arthroplasty

Joseph F DiBlasi, Ross P Smith, Jeffrey Garavaglia, Jeffrey Quedado, Benjamin M Frye, Matthew J Dietz  1
Affiliations
Comparative Study

Comparing Cost, Efficacy, and Safety of Intravenous and Topical Tranexamic Acid in Total Hip and Knee Arthroplasty

Joseph F DiBlasi et al. Am J Orthop (Belle Mead NJ). 2016 Nov/Dec.

Abstract

We conducted a study to compare the cost, efficacy, and safety of intravenous (IV) tranexamic acid (TXA) and topical TXA in primary total hip arthroplasty (THA) and total knee arthroplasty (TKA). We retrospectively reviewed the cases of 291 patients who received either IV TXA or topical TXA before and after surgery. Significant differences favored topical TXA in reducing the postoperative decrease in hemoglobin levels in THA (P = .031) and TKA (P = .015) and calculated blood loss in TKA (P = .019). The groups did not differ in transfusion requirements for either THA or TKA. Topical TXA cost significantly more than IV TXA (P ≤ .0001). The benefits of using topical TXA to reduce the perioperative decrease in hemoglobin levels come with increased cost.

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Conflict of interest statement

Authors’ Disclosure Statement: The authors report no actual or potential conflict of interest in relation to this article.

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