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Case Reports
. 2019 Nov;28(11):2602-2607.
doi: 10.1007/s00586-016-4861-1. Epub 2016 Dec 22.

The natural history of thoracolumbar kyphosis in achondroplasia

Malik Ahmed  1 , Mahmoud El-Makhy  2 , Michael Grevitt  2
Affiliations
Case Reports

The natural history of thoracolumbar kyphosis in achondroplasia

Malik Ahmed et al. Eur Spine J. 2019 Nov.

Abstract

There are little published data on the natural history and evolution of thoracolumbar kyphotic deformity in achondroplasia. Furthermore, there are few published reports indicating the probability of symptoms and at what kyphotic angle progressive deformity might occur. The lack of knowledge of the fundamental natural history does not allow firm guidelines for the management of this problem. In this respect the role of bracing remains uncertain both in terms of altering the prognosis for further vertebral wedging and overall sagittal profile. This report describes three illustrative cases of thoracolumbar kyphosis (TLK) that occurred in achondroplastic infants. The long-term outcomes are presented to illustrate the diverse clinical behaviour of TLK in this patient group.

Keywords: Achondroplasia; Bone dysplasias; Gibbus; Thoracolumbar kyphosis.

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References

    1. Bonaventure J, Rousseau F, Legeai-Mallet L, Le Merrer M, Munnich A, Maroteaux P (1996) Common mutations in the fibroblast growth factor receptor 3 (FGFR 3) gene account for achondroplasia, hypochondroplasia, and thanatophoric dwarfism. Am J Med Genet 63(1):148–154 - DOI
    1. Horton WA, Hall JG, Hecht JT (2007) Achondroplasia. Lancet 370(9582):162–172 - DOI
    1. Francomano CA (1995) The genetic basis of dwarfism. N Engl J Med 332(1):58–59 - DOI
    1. Pauli RM, Breed A, Horton VK, Glinski LP, Reiser CA (1997) Prevention of fixed, angular kyphosis in achondroplasia. J Pediatr Orthop 17(6):726–733 - PubMed
    1. Kopits SE (1988) Thoracolumbar kyphosis and lumbosacral hyperlordosis in achondroplastic children. Basic Life Sci 48:241–255 - PubMed

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